Validation of the novel ISUP-2014 5-tier Gleason grade grouping: Biochemical recurrence rates of 3+5 disease may be overestimated.

In 2014 the International Society of Urological Pathology (ISUP) supported to change the ISUP-2005 modified Gleason scoring system, as previously proposed by Pierorazio et al.[1,2] Besides decisions on terminology and scoring of specific morphological patterns, a renumbering of the existing scores was suggested.

[3] In clinical practice this comprises a transformation from a 6-10 risk spectrum including 9 different Gleason scores (3+3=6, 3+4=7, 4+3=7, 3+5=8 4+4=8, 5+3=8, 4+5=9, 5+4=9, and 5+5=10) to a 1-5 score with 5 grade groups (1: ≤3+3, 2: 3+4, 3: 4+3, 4: Gleason scores 8, and 5: Gleason score 9-10). This article is protected by copyright. All rights reserved.

BJU international. 2016 Mar 12 [Epub ahead of print]

Roderick Cn van den Bergh, Theo H van der Kwast, Jeroen de Jong, Homayoun Zargar, Andrew J Ryan, Anthony J Costello, Declan G Murphy, Henk G van der Poel

Royal Melbourne Hospital, Melbourne, Victoria, Australia., Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Netherlands Cancer Institute, Amsterdam, The Netherlands., Royal Melbourne Hospital, Melbourne, Victoria, Australia., TissuPath Specialist Pathology, Victoria, Australia., Royal Melbourne Hospital, Melbourne, Victoria, Australia., Royal Melbourne Hospital, Melbourne, Victoria, Australia., Netherlands Cancer Institute, Amsterdam, The Netherlands.

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