Follicular Lymphoma Showing Avid Uptake on 68Ga PSMA-HBED-CC PET/CT.

Ga prostate-specific membrane antigen (PSMA) PET/CT is a new imaging technique that is significantly more sensitive to prostate cancer lesions than other conventional imaging modalities. Various other benign and malignant neoplasms may also express PSMA and show uptake on PSMA PET/CT scan.

We report a case of 66-year-old man who had a PSMA PET/CT scan for restaging of prostate carcinoma. A PSMA-avid left femoral lymph node was identified. Subsequent biopsy confirmed the diagnosis of follicular lymphoma. It is important to be aware of this possibility to avoid scan misinterpretation. Biopsy of any atypical or clinically unexpected lesions should be considered.

Clinical nuclear medicine. 2016 Feb 24 [Epub ahead of print]

Gowri L Kanthan, Luke Coyle, Andrew Kneebone, Geoffrey Paul Schembri, Edward Hsiao

From the Departments of *Nuclear Medicine, and †Haematology, ‡Pathology North, and §Department of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.