Novel physical activity interventions for older patients with prostate cancer on hormone therapy: A pilot randomized study.

BACKGROUND - Androgen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC).

METHODS - We conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care arm in men ≥70years with PC receiving ADT.

The intervention lasted for 6weeks, with follow-up at 12weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score. Mixed effects regression models were used to assess change in outcomes over time.

RESULTS - Mean participant age was 70years (range: 67-93). Eight patients were randomized to the Wii-Fit arm, 6 to the EXCAP arm, and 5 to the usual-care arm. SPPB scores remained nearly constant in the usual-care arm (β=-0.12; p=0.79), while individuals in the EXCAP arm had on average a 1.2 point increase at each follow-up (β=1.20; 95% CI: 0.36, 2.06). The Wii-fit arm had a non-significant increase in SPPB score over time relative to usual-care (β=0.32; 95% CI -0.43, 1.06; p=0.46). Individuals in the EXCAP arm had an increase in steps per day over time compared to the usual-care arm (p-value=0.006); the EXCAP arm had an increase of 2720 steps (95% CI: 1313, 4128) while the usual-care arm had an increase of 97 steps (95% CI: -1140, 1333). Participants in the Wii-Fit arm had an increase of 1020 steps (95% CI: -474, 1238, p=0.710). Other outcomes (i.e., handgrip strength, lean muscle mass, and chest press repetitions) were not statistically significant.

CONCLUSIONS - A home-based aerobic and resistance exercise program, EXCAP, shows promise for improving PP in older men with PC on ADT.

Journal of geriatric oncology. 2016 Feb 22 [Epub ahead of print]

Saleha Sajid, William Dale, Karen Mustian, Ashwin Kotwal, Charles Heckler, Michelle Porto, Chunkit Fung, Supriya G Mohile

Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA.  Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA.  Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.  Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA., Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA., Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.  Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.  

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe