Anterior prostate cancer (APC) is defined as a tumour in which more than half of malignant tissue is located anterior to the urethra. APCs are increasingly recognized as clinically important, particularly in patients undergoing active surveillance and for patients with negative non-targeted systematic transrectal ultrasound (TRUS)-guided biopsies but with persistent clinical suspicion of cancer.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
Multiparametric (mp) MRI has a crucial role for the diagnosis of anterior tumours, eventual histological sampling of suspicious lesions using image-guided targeted biopsy techniques, and potentially, to improve local staging of disease. mpMRI is accurate for the detection of APC and for differentiation of tumour from other anterior prostatic structures including benign prostatic hyperplasia (BPH) and the anterior fibromuscular stroma (AFMS). Characterization and reporting of APC should rely on the recently revised Prostate Imaging and Data Reporting System (PI-RADS) version 2. 0 document. T2-weighted (T2W) imaging is emphasized as the determining sequence for assessment of the anterior prostate and specific features for APC on T2W imaging include: ill-defined/spiculated margin, lenticular shape, anterior/inferior location, and growth pattern (invasion of urethra or AFMS and crossing midline). Functional imaging, mainly with diffusion-weighted imaging, is also contributory and improves the sensitivity for detection of APC compared to T2W imaging alone. APCs commonly show positive surgical margins after radical prostatectomy and staging of disease extent using conventional clinical parameters is limited. mpMRI may have a future role to improve local staging of APC. This review illustrates the importance of mpMRI in APC using a clinical-radiological-histopathological approach.
Clinical radiology. 2016 Feb 14 [Epub ahead of print]
B Moosavi, T A Flood, O Al-Dandan, R H Breau, I Cagiannos, C Morash, S C Malone, N Schieda
Department of Medical Imaging, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Room C120, Ottawa, ON K1Y4E9, Canada. , Department of Anatomic Pathology, The Ottawa Hospital, 501 Smyth Road, 4th Floor CCW, Room 4278, Ottawa, ON K1H8L6, Canada. , Department of Radiology, University of Dammam, Dammam, Saudi Arabia. , Department of Surgery, Division of Urology, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. , Department of Surgery, Division of Urology, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. , Department of Surgery, Division of Urology, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. , Department of Radiation Oncology, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. , Department of Medical Imaging, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Room C120, Ottawa, ON K1Y4E9, Canada.