AIM OF STUDY - Gleason score stratification according to age at diagnosis has been retrospectively evaluated in 1028 men with biopsy-proven prostate cancer (PCa).
MATERIALS AND METHODS - From January 2006 to December 2014, 2435 Caucasian men aged between 37 and 92 years underwent transperineal prostate biopsy for suspicion of PCa.
The indications were as follows: abnormal digital rectal examination (DRE), PSA values > 10 ng/ml or between 4. 1-10 or 2. 6-4 ng/ml, with free/total PSA < 25% and < 20%, respectively.
RESULTS - In 1028 (42. 2%) patients with median PSA of 9. 6 ng/ml a PCa was found (median age 62. 3 years; range: 42-92 years); 757 (73. 7%) vs. 271 (26. 3%) men had a T1c vs. T2 clinical stage, respectively. Median Gleason score was 7 (range: 6-10). The Gleason score progressively increased with the age of the patients at diagnosis, and a significantly correlation between Gleason score ≥ 8 and men older than 80 years was demonstrated (p = 0. 0001).
CONCLUSIONS - The detection rate of aggressiveness of PCa progressively increased with the age at diagnosis; Gleason score ≥ 8 was more frequently diagnosed in men older than 80 years with PSA values > 10 ng/ml (about 80% of the cases) and abnormal DRE (about 60% of the cases).
Contemporary oncology (Poznań, Poland). 2016 Jan 13 [Epub]
Pietro Pepe, Michele Pennisi
Urology Unit, Cannizzaro Hospital, Catania, Italy. , Urology Unit, Cannizzaro Hospital, Catania, Italy.