Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution.

It is becoming characteristically more understandable that within tumor cells, there lies a sub-population of tumor cells with "stem cell" like properties and remarkable ability of self-renewal.

Many features of these self-renewing cells are comparable with normal stem cells and are termed as "cancer stem cells". Accumulating experimentally verified data has started to scratch the surface of spatio-temporally dysregulated intracellular signaling cascades in the biology of prostate cancer stem cells. We partition this multicomponent review into how different signaling cascades operate in cancer stem cells and how bioactive ingredients isolated from natural sources may modulate signaling network.

Archivum immunologiae et therapiae experimentalis. 2016 Feb 04 [Epub ahead of print]

Xiukun Lin, Ammad Ahmad Farooqi, Muhammad Zahid Qureshi, Mirna Azalea Romero, Sobia Tabassum, Muhammad Ismail

Department of Pharmacology, Capital Medical University, Beijing, People's Republic of China. , Laboratory for Translational Oncology and Personalized Medicine, RLMC, 35 Km Ferozepur Road, Lahore, Pakistan.  Department of Chemistry, GCU, Lahore, Pakistan. , Laboratorio de Investigación Clínica, Unidad Académica de Medicina, Universidad Autónoma de Guerrero, Av. Solidaridad S/N Col. Hornos Insurgentes, Acapulco, Guerrero, México. , Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan. , Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.

PubMed