The Caribbean island of Tobago, which is 97% African ancestry, has one of the highest rates of prostate cancer in the world. We have previously reported that human herpesvirus 8 (HHV-8) infection is significantly associated with prostate cancer in Tobago.
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In this study, we extend those results testing the hypothesis that HHV-8 seropositive Tobagonian men have a chronic HHV-8 infection in their prostates that is associated with increased inflammation.
Prostate sections were screened by immunohistochemistry for the expression of HHV-8 proteins K8. 1 and LANA-1 and for presence of B cells (CD20) and macrophages (CD68).
HHV-8 antigen expression representing lytic and latent infections was seen in 73. 9% of prostates from HHV-8 seropositive subjects. Latent infections were seen predominantly in glandular epithelia whereas lytic gene expression was seen mainly in macrophages in prostate stroma. Macrophage infiltrates were significantly increased in sections expressing HHV-8 proteins.
HHV-8 establishes a chronic latent infection in the prostate, which is associated with an increased macrophage infiltrate. Prostate © 2016 Wiley Periodicals, Inc.
The Prostate. 2016 Feb 05 [Epub ahead of print]
Jill D Henning, Clareann H Bunker, Alan L Patrick, Frank J Jenkins
Department of Biology, University of Pittsburgh Johnstown, Johnstown, Pennsylvania. , Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania. , Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago, West Indies. , Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.