Trichomonas vaginalis infection and risk of advanced prostate cancer.

BACKGROUND - The epidemiologic evidence for an association of Trichomonas vaginalis (Tv) with overall prostate cancer is mixed, but some studies suggest Tv may increase risk of more aggressive disease. The aim of this study was to assess whether Tv serostatus is associated with advanced or fatal prostate cancer.

METHODS - A total of 146 men with advanced (metastatic or fatal) prostate cancer and 181 age-matched controls were selected from two prior population-based, case-control studies. Tv serostatus was determined with the same laboratory methods used in previous epidemiologic studies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression to compare Tv serostatus in prostate cancer cases and controls adjusted for potential confounders.

RESULTS - The seroprevalence of Tv in controls was 23%. Tv serostatus was not associated with an increased risk of metastatic or fatal prostate cancer (ORs < 1).

CONCLUSIONS - Our study does not support an increased risk of advanced or fatal prostate cancer in men seropositive for Tv. Prostate © 2016 Wiley Periodicals, Inc.

The Prostate. 2016 Jan 28 [Epub ahead of print]

Irene M Shui, Suzanne Kolb, Christi Hanson, Siobhan Sutcliffe, Jennifer R Rider, Janet L Stanford

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. , Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. , Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. , Division of Public Health Sciences and the Alvin J Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri. , Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts. , Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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