Missing link between microRNA and prostate cancer.

MicroRNAs are the non-coding RNAs which regulate endogenous gene expression in animal and plant cells. Alterations in the level of micro-ribonucleic acids (miRNAs) involving the deletions, overexpression, mutations, epigenetic silencing, or dysregulation of transcription factors that target specific miRNAs may culminate in various diseases including cancer.

Recent findings demonstrate the role of miRNAs in prostate cancer. Numerous discoveries of miRNAs have marked the research and development surrounding prostate cancer management, diagnosis, and therapy which has made prediction easy, but the effective treatment strategy remains a mystery. This review seeks to draw a link between miRNA and prostate cancer through an understanding of the numerous signaling pathways that these miRNAs control, which may prove to be helpful in identifying therapeutically interesting molecular targets.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 Jan 28 [Epub ahead of print]

Balraj Singh Gill, Jimi Marin Alex, Sanjeev Kumar

Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India. , Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India. , Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India. 

PubMed

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