The treatment of high-risk prostate cancer requires a multimodal approach to improve control of the disease. There is still no consensus as to the initial strategy of choice. The aim of this study is to review the results of radical prostatectomy as first step in management of patients with high-risk disease.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
A search was conducted on PubMed of English and Spanish texts. We included those studies that reported the results of radical prostatectomy in patients with high-risk prostate cancer, as well as those that compared radical prostatectomy with other treatment alternatives. The last search was conducted in November 2015.
The advantages of radical prostatectomy include a better pathological analysis, more accurate staging, better local control of the disease and better follow-up and adjuvant therapy strategies. When compared with external radiation therapy plus hormonal blockade, the patients who underwent prostatectomy had greater chances of healing and longer cancer-specific survival. The patients who most benefit from this approach are younger, have fewer comorbidities and no evidence of organ metastases.
The available scientific evidence to date is not without bias and confounders; however, they appear to favour radical prostatectomy as the initial approach of choice for high-risk prostate cancer.
Actas urologicas espanolas. 2016 Jan 12 [Epub ahead of print]
J H Jaunarena, W Villamil, P F Martínez, G Gueglio, C R Giudice
Servicio de Urología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Servicio de Urología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , Servicio de Urología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , Servicio de Urología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , Servicio de Urología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.