The new insight of prostate-specific antigen reduction during finasteride therapy in aging men.

To evaluate the effect of finasteride on prostate-specific antigen (PSA) in Chinese population.

From Feb 2011 to Jan 2012, 83 benign prostatic hyperplasia (BPH) patients with prostate volume (PV) >30 mL were enrolled in our study.

All the patients were older than 50 years and all of them received combined therapy (finasteride + doxazosin). All the patients were required for 1-year follow-up. PSA level and PV was measured at the start, 6 and 12 months, respectively.

79 patients completed the follow up. PSA level reduced by approximately 40 % during finasteride therapy. We defined baseline PSA as PSA1, PSA at 6 months as PSA2, PSA at 12 months as PSA3. PSA1 was significantly correlated with PSA2/PSA1 and PSA3/PSA1. However, prostate volume was not correlated with PSA1. We divided the patients into three groups according to PSA level. Groups 1, 2, 3 represented the patients with PSA less than 2 ng/mL, between 2 and 4 ng/mL and greater than 4 ng/mL, respectively. Both the PSA2/PSA1 and the PSA3/PSA1 had significant difference among three groups. Furthermore, group 1 and group 2 both showed the fairly large data variance.

When baseline PSA level was greater than 4 ng/mL, the doubling rule could be used for screening. When baseline PSA level was less than 4 ng/Ml, the doubling rule might not be an accurate predictor. We can use the PSA rise from nadir or proPSA to predict prostate cancer.

Aging clinical and experimental research. 2016 Jan 11 [Epub ahead of print]

Ding Xu, Jie Ding, Yunkai Zhu, Xiaoqiang Qian, Liujian Duan, Jun Qi

Department of Urology, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. , Department of Urology, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. , Department of Ultrasound, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, Shanghai, China. , Department of Urology, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. , Department of Urology, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. , Department of Urology, XinHua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. 

PubMed

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