Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy.

AIM - To investigate the time course of testosterone (T) recovery after cessation of androgen deprivation therapy (ADT) in patients treated with brachytherapy.

METHODS - One-hundred and seventy-four patients treated between June 1999 and February 2009 were studied.

Patients were divided into a short-term usage group (≤ 12 mo, n = 91) and a long-term usage group (≥ 36 mo, n = 83) according to the duration of gonadotropin-releasing hormone agonist therapy. Median follow-up was 29 mo in the short-term group and was 60 mo in the long-term group.

RESULTS - Cumulative incidence rates of T recovery to normal and supracastrate levels at 24 mo after cessation were 28. 8% and 74. 6%, respectively, in the long-term usage group, whereas these values were 96. 4% and 98. 8% in the short-term usage group. T recovery to normal and supracastrate levels occurred significantly more rapidly in the short-term than in the long-term usage group (P < 0. 001 and P < 0. 001, respectively). Five years after cessation, 22. 6% of patients maintained a castrate T level in the long-term usage group. On multivariate analysis, lower T levels (< 10 ng/dL) at cessation of ADT was significantly associated with prolonged T recovery to supracastrate levels in the long-term usage group (P = 0. 002).

CONCLUSIONS - Lower T levels at cessation of ADT were associated with prolonged T recovery in the long-term usage group. Five years after cessation of long-term ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery.

World journal of radiology. 2015 Dec 28 [Epub]

Hideyasu Tsumura, Takefumi Satoh, Hiromichi Ishiyama, Shuhei Hirano, Ken-Ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Masashi Kitano, Shiro Baba, Kazushige Hayakawa, Masatsugu Iwamura

Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan. , Hideyasu Tsumura, Takefumi Satoh, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Shiro Baba, Masatsugu Iwamura, Department of Urology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

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