Hoxb13, a potential prognostic biomarker for prostate cancer.

HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. HOXB13 is overexpressed during malignant progression of the prostatic tissue and suspected to contribute in the pathogenesis of the prostate gland.

In androgen deprived conditions, HOXB13 is thought to act through inhibition of the tumour suppressor protein p21. Since HOXB13 has a multifaceted role in ventral prostate development, its critical partners in the cascade need to be elucidated for a further understanding of its role in prostate malignancy. In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer.

Frontiers in bioscience (Elite edition). 2016 Jan 01*** epublish ***

Allal Ouhtit, Mohammed N Al-Kindi, Parvathy R Kumar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

Department of Biological and Environmental Sciences, College of Arts & Sciences, Qatar University, Qatar, Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, POBox35, PC 123, Al Khoud, Sultanate of Oman. , Department of Genetics, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman. , Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman. , Department of Genetics, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman. , Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, POBox35, PC 123, Al Khoud, Sultanate of Oman.

PubMed

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