We examined the association between omega-3 fatty acids (O3FAs) and prostate-specific antigen (PSA) in a cross-sectional analysis of 6219 men examined at the Cooper Clinic from 2009 to 2013. We assayed O3FAs from red blood cell membranes and measured PSA levels in study participants.
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Multiple logistic regression was used to examine the association between O3FAs and PSA. The mean age of study participants was 55. 5 years (SD = 9. 8) with a mean PSA level of 1. 31 ng/mL (SD = 1. 5). Unadjusted analyses indicated that there was a slight, direct association with PSA and each of the O3FAs tested. However, after adjusting for age and body mass index (BMI), the associations were reversed but nonsignificant [odds ratio (OR) for PSA > 4 ng/mL: total omega-3 OR = 0. 98 per each 1% of total fatty acids, 95% confidence interval (CI) = 0. 93-1. 03; docosahexaenoic acid OR = 1. 01, 95% CI = 0. 92-1. 11; omega-3 index OR = 0. 99, 95% CI = 0. 93-1. 05). Similar results were obtained after age and BMI adjustment when the omega-3 index was divided into undesirable (0. 01-3. 99%), intermediate (4. 0-7. 99%), and desirable ranges ( ≥ 8. 0%). Given that the study had >80% power to detect an odds ratio <0. 9 or >1. 1, we conclude that associations between O3FAs and PSA levels are either nonexistent or quite weak in the population that this healthy sample represents.
Nutrition and cancer. 2015 Dec 28 [Epub ahead of print]
Laura F DeFina, Mary H Bassett, Carrie E Finley, Carolyn E Barlow, Benjamin L Willis, Tyler Cooper, S Michael Clark, William S Harris, Nina B Radford
a The Cooper Institute , Dallas , Texas , USA. , b School of Public Health, The University of Texas Health Science Center , Dallas , Texas , USA. , a The Cooper Institute , Dallas , Texas , USA. , c The Cooper Institute, School of Public Health, The University of Texas Health Science Center , Dallas , Texas , USA. , a The Cooper Institute , Dallas , Texas , USA. , d Cooper Clinic , Dallas , Texas , USA. , d Cooper Clinic , Dallas , Texas , USA. , e OmegaQuant , Sioux Falls , South Dakota , USA. , d Cooper Clinic , Dallas , Texas , USA.