Prostate cancer is the most commonly diagnosed non-cutaneous malignancy in men in western and most developing countries. Bicalutamide (BLT) is an antineoplastic hormonal agent primarily used in the treatment of locally advanced and metastatic prostate cancers.
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In the present study, the aim was to develop a nanotechnology-based delivery system to target prostate cancer cells. This involved the development of a BLT-loaded poly(D,L-lactide-co-glycolide) PLGA (PLGA-BLT) nanoparticulate system in an attempt to improve the therapeutic efficacy of BLT in prostate cancer and to mitigate its toxicity. Nanosized particles with a uniform size distribution and spherical shape were developed. PLGA-BLT showed a pronounced cytotoxic effect on LNCaP and C4-2 cancer cells. The superior cell-killing effect of the nanoparticles may be attributable to their sustained drug-release characteristics and high cellular internalization. PLGA-BLT was also found to significantly inhibit colony formation in the two cell lines. Furthermore, the caspase-3 activity of PLGA-BLT treated cancer cells was enhanced, indicating the cell apoptosis-inducing potential of PLGA-BLT. Overall, these results suggest that nanotechnology-based formulations of BLT exhibit superior anticancer activity and have enormous potential in the treatment of prostate cancers.
Experimental and therapeutic medicine. 2015 Oct 14 [Epub]
Jun Guo, Shu-Hong Wu, Wei-Guo Ren, Xin-Li Wang, Ai-Qing Yang
Department of Urology, The Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P. R. China. , Department of Urology, Feicheng Kuangye Central Hospital, Feicheng, Shandong 271608, P. R. China. , Department of Urology, Rugao Boai Hospital, Nantong, Jiangsu 226500, P. R. China. , Department of Pathology, The Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P. R. China. , Department of Pathology, The First People's Hospital of Taian, Taian, Shandong 271000, P. R. China.