Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study

Transrectal-ultrasound-guided prostate biopsy (TRUS-PBx) is the standard procedure for diagnosing prostate cancer. The procedure does cause some pain and discomfort; therefore, an adequate analgesia is necessary to ensure patient comfort, which can also facilitate good-quality results.

This prospective, randomized, double-blinded, placebo-controlled study aimed to determine if intravenous (IV) paracetamol can reduce the severity of pain associated with TRUS-PBx. The study included 104 patients, scheduled to undergo TRUS-PBx with a suspicion of prostate cancer, that were prospectively randomized to receive either IV paracetamol (paracetamol group) or placebo (placebo group) 30 minutes prior to TRUS-PBx. All patients had 12 standardized biopsy samples taken. Pain was measured using a 10-point visual analog pain scale during probe insertion, during the biopsy procedure, and 1 hour postbiopsy. All biopsies were performed by the same urologist, whereas a different urologist administered the visual analog pain scale. There were not any significant differences in age, prostate-specific antigen level, or prostate volume between the two groups. The pain scores were significantly lower during probe insertion, biopsy procedure, and 1 hour postbiopsy in the paracetamol group than in the placebo group. In conclusion, the IV administration of paracetamol significantly reduced the severity of pain associated with TRUS-PBx.

The Kaohsiung journal of medical sciences. 2015 Oct 21 [Epub]

Ozcan Kilic, Murat Akand, Haluk Kulaksizoglu, Ahmet H Haliloglu, Seher Tanidik, Mehmet M Piskin, Talat Yurdakul

Department of Urology, School of Medicine, Selcuk University, Konya, Turkey. , Department of Urology, School of Medicine, Selcuk University, Konya, Turkey. Department of Urology, School of Medicine, Bilim University, Istanbul, Turkey. , Department of Urology, School of Medicine, Ufuk University, Ankara, Turkey. , Department of Biochemistry, Medicana Hospital, Konya, Turkey. , Department of Urology, Meram Medical School, Necmettin Erbakan University, Konya, Turkey. , Department of Urology, Kolan International Hospital Şişli, Istanbul, Turkey.

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