Detection of Bone Metastases Using 11C-Acetate PET in Patients with Prostate Cancer with Biochemical Recurrence.

To evaluate the diagnostic accuracy of (11)C-acetate positron-emission tomography (PET) in the detection of bone metastasis in patients with prostate cancer with biochemical recurrence.

Ninety patients (100%) with rising prostate-specific antigen (PSA) levels (>0.

2 ng/ml) after radical prostatectomy, who had both (11)C-acetate PET and bone scan performed and who had clinical follow-up/imaging follow-up for bone metastasis, considered a gold standard, were included. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for (11)C-acetate PET were calculated on a per-patient basis.

(11)C-Acetate PET and (99m)Tc-dicarboxypropane-diphosphonate findings were concordant in 84 (93. 3%) patients [35 (38. 9%) true-positive, 49 (54. 4%) true-negative]. Discordant findings were observed in six patients (6. 7%). (11)C-Acetate PET presented two (2. 2%) false-positive and four (4. 4%) false-negative findings. The sensitivity, specificity, PPV, and NPV for (11)C-acetate PET were 89. 7%, 96. 1%, 94. 6%, and 92. 2%, respectively. The median PSA of patients with multiple skeletal metastases (median=23. 64 ng/ml, range=3. 16-551. 1 ng/ml) differed significantly (p=0. 018) from that of patients with focal metastases (median=6. 7 ng/ml, range=0. 31-12. 8 ng/ml).

(11)C-Acetate PET is a useful tool for patients with prostate cancer with biochemical recurrence, as it can depict multiple sites of recurrence and in particularly shows a high diagnostic value equivalent to that of bone scan for the detection of bone metastases.

Anticancer research. 2015 Dec [Epub]

Claudio Spick, Stephan H Polanec, Markus Mitterhauser, Wolfgang Wadsak, Philip Anner, Bettina Reiterits, Alexander R Haug, Marcus Hacker, Mohsen Beheshti, Georgios Karanikas

Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. , PET-CT Center Linz, Department of Nuclear Medicine and Endocrinology, St. Vincent's Hospital, Linz, Austria. , Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria georgios.  

PubMed