Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation.

Objectives. To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities. Methods. One hundred and seven men (42-89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis.

A cross-sectional analysis was undertaken to investigate the potential impact of therapy exposure with participants stratified into two groups according to duration of androgen deprivation therapy (

Advances in urology. 2015 Oct 26 [Epub]

Bradley A Wall, Daniel A Galvão, Naeem Fatehee, Dennis R Taaffe, Nigel Spry, David Joseph, Robert U Newton

School of Psychology and Exercise Science, Murdoch University, Murdoch, WA 6150, Australia ; Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia ; School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia ; Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia ; Faculty of Medicine, University of Western Australia, Nedlands, WA 6009, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia ; Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia ; Faculty of Medicine, University of Western Australia, Nedlands, WA 6009, Australia. , Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia ; Centre for Clinical Research, The University of Queensland, Herston, QLD 4006, Australia.

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