Sextant-Specific Analysis of Detection and Tumor Volume by HistoScanning™.

INTRODUCTION - Published results of HistoScanning™ (HS) for prostate cancer (PCa) diagnostics are inconsistent and their value remains unclear. We prospectively analyzed the detection rate and tumor volume concordance in PCa patients.

MATERIALS AND METHODS - Two hundred and eighty-two patients with biopsy-proven PCa scheduled for radical prostatectomy (RP) were included. All patients underwent ultrasonographical examination by HS prior to surgery. HS was evaluated compared to RP specimen as to (1) the prediction of overall tumor volume and (2) accuracy of HS in detection of PCa lesions larger than 0. 2/0. 5 ml, separated for each sextant. For each sextant, receiver operating characteristic (ROC)-analysis and area under the curve were determined. Sensitivity and specificity were calculated and visualized in ROC-curves.

RESULTS - HS tends to underestimate volume of cancerous lesions, particularly larger lesions >8 ml. Using a 0. 2 ml detection threshold, specificity and sensitivity of HS were between 29-68% and 46-78%. For a 0. 5 ml detection threshold, sextant-specific specificity increased to 59-92% and sensitivity decreased to 16-54%. Stratification according to pre-operational PSA values did not improve performance characteristics of HS.

CONCLUSIONS - Our results do not support a significant contribution of HS to PCa diagnostics.

Urologia internationalis. 2015 Nov 11 [Epub ahead of print]

Daniel Porres, Timur Hasan Kuru, Robin Epplen, Andreas Eck, Vahudin Zugor, Lieven Niels Kennes, Samir Afram, Till Braunschweig, Ruth Knüchel-Clarke, David Pfister, Axel Heidenreich

Department of Urology,RWTH University, Aachen, Germany.



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