Changes in physical functioning and muscle strength in men receiving androgen deprivation therapy for prostate cancer: a controlled comparison.

The purpose of the study is to examine changes in muscle strength and self-reported physical functioning in men receiving androgen deprivation therapy (ADT) for prostate cancer compared to matched controls.

Prostate cancer patients scheduled to begin ADT (n = 62) were assessed within 20 days of starting ADT and 6 and 12 months later. Age and geographically matched prostate cancer controls treated with prostatectomy only (n = 86) were assessed at similar time intervals. Grip strength measured upper body strength, the Chair Rise Test measured lower body strength, and the SF-12 Physical Functioning scale measured self-reported physical functioning.

As expected, self-reported physical functioning and upper body muscle strength declined in ADT recipients but remained stable in prostate cancer controls. Contrary to expectations, lower body muscle strength remained stable in ADT recipients but improved in prostate cancer controls. Higher Gleason scores, more medical comorbidities, and less exercise at baseline predicted greater declines in physical functioning in ADT recipients.

ADT is associated with declines in self-reported physical functioning and upper body muscle strength as well as worse lower body muscle strength relative to prostate cancer controls. These findings should be included in patient education regarding the risks and benefits of ADT. Findings also underscore the importance of conducting research on ways to prevent or reverse declines in physical functioning in this patient population.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2015 Nov 13 [Epub ahead of print]

Brian D Gonzalez, Heather S L Jim, Brent J Small, Steven K Sutton, Mayer N Fishman, Babu Zachariah, Randy V Heysek, Paul B Jacobsen

Division of Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. , Health Outcomes and Behavior Program, Moffitt Cancer Center, 12902 Magnolia Drive MRC-ADMIN, Tampa, FL, 33612, USA. , School of Aging Studies, University of South Florida, Tampa, FL, USA. , Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA. , Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA. , Department of Radiation Oncology, James A. Haley Veterans' Hospital, Tampa, FL, USA. , Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA. , Health Outcomes and Behavior Program, Moffitt Cancer Center, 12902 Magnolia Drive MRC-ADMIN, Tampa, FL, 33612, USA. 

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