The TMPRSS2:ERG (T2E) gene fusion is the most common rearrangement in prostate cancer (PCa). It is unknown if these molecular subtypes have a different etiology. We evaluated aspirin and non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in association with T2E fusion status.
Subjects were from a population-based case-control study of PCa. T2E fusion status for prostatectomy cases (n=346) was determined by fluorescence in situ hybridization. Medication use was determined from questionnaires. Logistic regression, controlling for age, race, PCa family history and PSA screening, was used to evaluate the association of T2E fusion status according to medication use.
T2E fusion was present in 171 (49%) cases, with younger cases more likely to be fusion positive (P
Aspirin was associated with a significant reduction in the relative risk of T2E fusion positive, but not T2E negative, PCa. As inflammation and androgen pathways are implicated in prostate carcinogenesis, additional studies of anti-inflammatory medications in relation to these PCa subtypes are warranted. Prostate Cancer and Prostatic Diseases advance online publication, 27 October 2015; doi:10. 1038/pcan. 2015. 49.
Prostate cancer and prostatic diseases. 2015 Oct 27 [Epub ahead of print]
J L Wright, L Chéry, S Holt, D W Lin, M Luedeke, A E Rinckleb, C Maier, J L Stanford
Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. , Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. , Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. , Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. , Department of Urology, University of Ulm, Ulm, Germany. , Department of Urology, University of Ulm, Ulm, Germany. , Department of Urology, University of Ulm, Ulm, Germany. , Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.