We evaluated the biochemical recurrence (BCR) of prostate cancer patients treated by radical prostatectomy (RP) or radiotherapy (RT).
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Patients who underwent RP or RT as primary definitive treatment from 2007 were enrolled for this study.
They were divided into two groups; the low-intermediate risk group and the high risk group according to the National Comprehensive Cancer Network guidelines. We compared differences such as age, prostate specific antigen, Gleason score, follow-up duration, clinical T staging, and BCR. Their BCR-free survival rates were analyzed.
A total of 165 patients were enrolled. There were 115 patients in the low-intermediate risk. Among them, 88 received RP and 27 underwent RT. BCR occurred in 9 of the RP patients (10. 2%) and 3 of the RT patients (11. 1%). For the high risk group, 50 patients were included. RP was performed in 25 patients and RT in 25 patients. BCR was observed in 4 of the RP patients (16%) and 12 of the RT patients (48%). There were no differences in BCR-free survival for the low-intermediate group (p=0. 765). For the high risk group, the RP group had a higher BCR free survival rate (p=0. 032).
No difference of BCR and BCR-free survival was seen in the low-intermediate risk group but lower BCR and better BCR-free survival were observed for patients that received RP in the high risk group. RP should be a more strongly considered option when deciding the treatment method for selected high risk patients.
Korean journal of urology. 2015 Oct 02 [Epub]
Dong Soo Kim, Seung Hyun Jeon, Sung-Goo Chang, Sang Hyub Lee
Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea. , Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea. , Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea. , Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.