To assess whether larger tumor volume in black men explains higher presurgical PSA levels versus white men with prostate cancer.
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We retrospectively analyzed 1904 men from the Shared Equal Access Regional Cancer Hospital database who underwent radical prostatectomy from 1990 to 2013.
Geometric mean of tumor volume and preoperative PSA for each race were estimated from multivariable linear regression models.
There were 1104 (58%) white men and 800 (42%) black men. Black men were younger (60. 2 vs. 62. 9 years, p
In this study of men undergoing radical prostatectomy at multiple equal access medical centers, racial differences in tumor volume did not explain higher presurgical PSA levels in black versus white men. The exact reason for higher PSA values in black men remains unclear.
Cancer epidemiology. 2015 Oct 06 [Epub ahead of print]
Zachary Klaassen, Lauren Howard, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane, Stephen J Freedland
Medical College of Georgia-Georgia Regents University, Augusta, GA, United States. , Duke University Medical Center, Durham, NC, United States. , Medical College of Georgia-Georgia Regents University, Augusta, GA, United States; Augusta Veterans Affairs Medical Center, Augusta, GA, United States. , West Los Angeles Veterans Affairs Medical Center, West Los Angeles, CA, United States; University of California, Los Angeles School of Medicine, Los Angeles, CA, United States. , San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States; University of California, San Francisco, CA, United States. , Oregon Health & Sciences University, Portland, OR, United States. , San Diego Veterans Affairs Medical Center, San Diego, CA, United States; University of California, San Diego, CA, United States. , Durham Veterans Affairs Medical Center, Durham, NC, United States; Cedars Sinai Medical Center, Los Angeles, CA, United States.