The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).
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Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.
For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0. 05) for T1/T2RI (0. 60 and 0. 62, respectively) than for T2WI (0. 54 and 0. 56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.
T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.
Prostate international. 2015 Jul 17 [Epub]
Ja Yeon You, Hak Jong Lee, Sung Il Hwang, Yun Jung Bae, Hannah Kim, Helen Hong, Gheeyoung Choe
Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea. , Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea ; Program in Nano Science and Technology, Department of Transdisciplinary Studies, Seoul National University Graduate School of Convergence Science and Technology, Suwon, South Korea. , Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea. , Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea. , Department of Computer Science and Engineering, Seoul Women's University, Seoul, South Korea. , Department of Multimedia Engineering, Seoul Women's University, Seoul, South Korea. , Department of Pathology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.