Improving the (18) F-fluoromethylcholine ((18) F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added (18) F-fluorine.

(18) F-Fluoromethylcholine ((18) F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia.

We acknowledged the major problem with (18) F-FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved (18) F-FCH radiochemical yields after carrying out optimisation on azeotropic drying of non-carrier-added (18) F-Fluorine.

Journal of labelled compounds & radiopharmaceuticals. 2015 Sep 23 [Epub ahead of print]

Hishar Hassan, Suharzelim Abu Bakar, Khairul Najah Che A Halim, Jaleezah Idris, Fathinul Fikri Ahmad Saad, Abdul Jalil Nordin

Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia. , National Cancer Institute, Putrajaya, Malaysia. , National Cancer Institute, Putrajaya, Malaysia. , National Cancer Institute, Putrajaya, Malaysia. , Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia. , Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia.

PubMed