A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia

A diverse body of evidence suggests that lycopene might inhibit prostate cancer development. We conducted a 6-mo repeat biopsy randomized trial among men with high-grade prostatic intraepithelial neoplasia (HGPIN).

Here we report results for serum lycopene, prostate specific antigen (PSA) and insulin-like growth factor (IGF) proteins, histopathological review, and tissue markers for proliferation [minichromosome maintenance protein 2 (MCM-2)] and cell cycle inhibition (p27). Participants consumed placebo or tomato extract capsules containing 30 mg/day lycopene. Pre- and posttreatment biopsies were immunostained and digitally scored. Serum lycopene was determined by LC-MS-MS. In secondary analyses, pathologists blindly reviewed each biopsy to score histological features. Fifty-eight men completed the trial. Serum lycopene increased 0. 55 μmol/L with treatment and declined 0. 29 μmol/L with placebo. We observed no meaningful differences in PSA, IGF-1, or IGF binding protein 3 concentrations between groups, nor any differences in expression of MCM-2 or p27 in epithelial nuclei. Prevalences of cancer, HGPIN, atrophy, or inflammation posttreatment were similar; however, more extensive atrophy and less extensive HGPIN was more common in the lycopene group. Despite large differences in serum lycopene following intervention, no treatment effects were apparent on either the serum or benign tissue endpoints. Larger studies are warranted to determine whether changes observed in extent of HGPIN and focal atrophy can be replicated.

Nutrition and cancer. 2015 Oct [Epub]

Peter H Gann, Ryan J Deaton, Erika Enk Rueter, Richard B van Breemen, Larisa Nonn, Virgilia Macias, Misop Han, Viju Ananthanarayanan

a Department of Pathology , University of Illinois at Chicago , Chicago , Illinois , USA. , a Department of Pathology , University of Illinois at Chicago , Chicago , Illinois , USA. , a Department of Pathology , University of Illinois at Chicago , Chicago , Illinois , USA. , b Department of Medicinal Chemistry and Pharmacognosy , University of Illinois at Chicago , Chicago , Illinois , USA. , a Department of Pathology , University of Illinois at Chicago , Chicago , Illinois , USA. , a Department of Pathology , University of Illinois at Chicago , Chicago , Illinois , USA. , c Department of Urology , Johns Hopkins University , Baltimore , Maryland , USA. , d Department of Pathology , Loyola University Medical Center , Maywood , Illinois , USA.

PubMed

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