Prostate cancer (PCa) subtypes based on ETS gene expression have been described. Recent studies suggest there are racial differences in tumor location, with PCa located anteriorly more often among African-American (AA) compared to Caucasian-American (CA) men.
In this retrospective analysis of a multi-institutional cohort treated by radical prostatectomy (179 CA, 121 AA), we evaluated associations among molecular subtype, race, anatomic tumor location, and androgen receptor (AR) signaling. Subtype (m-ERG(+), m-ETS(+), m-SPINK1(+), or triple-negative) was determined using distribution-based outlier analysis. AR signaling was investigated using gene expression profiling of canonical AR targets. m-ERG(+) was more common in CA than AA men (47% vs 22%, p
This study demonstrates associations among patient race, prostate cancer molecular subtypes, and tumor location. Location-specific differences in androgen regulation may further underlie these relationships.
European urology. 2015 Oct 03 [Epub ahead of print]
Farzana A Faisal, Debasish Sundi, Jeffrey J Tosoian, Voleak Choeurng, Mohammed Alshalalfa, Ashley E Ross, Eric Klein, Robert Den, Adam Dicker, Nicholas Erho, Elai Davicioni, Tamara L Lotan, Edward M Schaeffer
Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. , Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. , GenomeDx Biosciences, Vancouver, BC, Canada. , GenomeDx Biosciences, Vancouver, BC, Canada. , Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. , Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. , Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. , Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. , GenomeDx Biosciences, Vancouver, BC, Canada. , GenomeDx Biosciences, Vancouver, BC, Canada. , Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. , Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.