Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: critical evaluation using whole-mount pathology as standard of reference.

To evaluate the recommendations for multiparametric prostate MRI (mp-MRI) interpretation introduced in the recently updated Prostate Imaging Reporting and Data System version 2 (PI-RADSv2), and investigate the impact of pathologic tumour volume on prostate cancer (PCa) detectability on mpMRI.

This was an institutional review board (IRB)-approved, retrospective study of 150 PCa patients who underwent mp-MRI before prostatectomy; 169 tumours ≥0. 5-mL (any Gleason Score [GS]) and 37 tumours

PI-RADSv2 allowed correct identification of 118/125 (94 %; 95 %CI: 90-99 %) peripheral zone (PZ) and 42/44 (95 %; 95 %CI: 89-100 %) transition zone (TZ) tumours ≥0. 5 mL, but only 7/27 (26 %; 95 %CI: 10-42 %) PZ and 2/10 (20 %; 95 %CI: 0-52 %) TZ tumours with a GS ≥4+3, but

PI-RADSv2 correctly identified 94-95 % of PCa foci ≥0. 5 mL, but was limited for the assessment of GS ≥4+3 tumours ≤0. 5 mL. DCE-MRI offered limited added value to T2WI+DW-MRI.

• PI-RADSv2 correctly identified 95 % of PCa foci ≥0. 5 mL • PI-RADSv2 was limited for the assessment of GS ≥4+3 tumours ≤0. 5 mL • DCE-MRI offered limited added value to T2WI+DW-MRI.

European radiology. 2015 Sep 22 [Epub ahead of print]

H A Vargas, A M Hötker, D A Goldman, C S Moskowitz, T Gondo, K Matsumoto, B Ehdaie, S Woo, S W Fine, V E Reuter, E Sala, H Hricak

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY, 10065, USA. Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY, 10065, USA. , Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY, 10065, USA. , Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Av. , New York, NY, 10065, USA. , Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY, 10065, USA. , Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY, 10065, USA.

PubMed