The purpose of this observational cohort study was to evaluate the outcome and prognostic factors following salvage radiotherapy (SRT) in a consecutive national cohort.
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Between 2006 and 2010, 259 patients received SRT in Denmark.
Patient- and cancer-related characteristics were retrospectively retrieved from patient charts. The primary end point was biochemical progression-free survival (b-PFS).
At the end of follow-up, 51% of the patients displayed a prostate-specific antigen (PSA) level
In patients treated for biochemical failure after RP, positive surgical tumour margins and PSA levels ≤0. 5 ng/mL at the time of SRT were associated with a favourable outcome. Despite less favourable tumour characteristics, patients receiving SRT and ADT demonstrated improved b-PFS, and in particular, patients with PSA levels >0. 2 ng/ml benefitted from additional ADT.
Acta oncologica (Stockholm, Sweden). 2015 Sep 23 [Epub ahead of print]
Maria Ervandian, Morten Høyer, Stine Elleberg Petersen, Lisa Sengeløv, Steinbjørn Hansen, Mats Holmberg, Joen Sveistrup, Peter Meidahl Petersen, Michael Borre
a Department of Urology , Aarhus University Hospital , Aarhus N , Denmark . , b Department of Oncology , Aarhus University Hospital , Aarhus C , Denmark . , b Department of Oncology , Aarhus University Hospital , Aarhus C , Denmark . , c Department of Oncology , Herlev Hospital , Herlev , Denmark . , d Department of Oncology , Odense University Hospital , Odense C , Denmark . , e Department of Oncology , Aalborg University Hospital , Aalborg , Denmark , and. , f Department of Oncology , Rigshospitalet , København Ø , Denmark. , f Department of Oncology , Rigshospitalet , København Ø , Denmark. , a Department of Urology , Aarhus University Hospital , Aarhus N , Denmark .