Relationship between non-suspicious MRI and insignificant prostate cancer: results from a monocentric study.

To assess whether non-suspicious multiparametric magnetic-resonance imaging (mpMRI) was associated with no cancer or indolent prostate cancer (PCa) in subsequent biopsies.

Retrospective analyses of a prospective database were conducted between 2009 and 2013.

It included men with an abnormal digital rectal examination and/or prostate-specific antigen levels

Seventy-eight patients with a negative MRI were included in the study; median patient age was 62 years (IQR 50-74). Median PSA level was 7. 15 ng/mL, with a median PSA density of 0. 15. The digital rectal examination was abnormal in eight cases. From MRI, 53 patients were Likert 2, 25 patients were Likert 1, and median prostate volume was 56. 5 mL. From biopsies, no cancer was found in 92. 3 % (n = 72). PCa was histologically confirmed in six patients (7. 7 %): five cases were indolent (as defined above); only one patient had a cancer core of 5 mm long, with a Gleason score of 6 (3 + 3). All six patients were within the low-risk group according to the D'Amico classification.

Men with non-suspicious mpMRI are likely to have no or indolent PCa in subsequent biopsies.

World journal of urology. 2015 Sep 24 [Epub ahead of print]

Raphaële Renard-Penna, Morgan Roupret, Eva Compérat, François Rozet, Benjamin Granger, Johann Barkatz, Marc Olivier Bitker, Olivier Lucidarme, Olivier Cussenot, Pierre Mozer

Academic Department of Radiology, AP-HP, Hopital Pitié-Salpétrière, 83 Bvd Hôpital, 75013, Paris, France.  Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France. , Academic Department of Pathology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France. , Urology Department, Montsouris Institute, 75014, Paris, France. , Academic Department of Biostatistics, Public Health and Medical Information, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France. , Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France. , Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France. , Academic Department of Radiology, AP-HP, Hopital Pitié-Salpétrière, 83 Bvd Hôpital, 75013, Paris, France. , Academic Department of Urology, AP-HP, Hopital Tenon, 75020, Paris, France. , Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.

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