Clinical effect of abiraterone acetate in Korean patients with metastatic castration-resistant prostate cancer according to duration of androgen deprivation therapy

Few data are available concerning the clinical outcome of abiraterone acetate treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) in terms of the duration of androgen deprivation therapy (ADT) before diagnosis of CRPC.

We investigated the clinical efficacy of abiraterone acetate according to the duration of ADT.

We reviewed the medical records of 20 patients with mCRPC who received abiraterone acetate after failure of docetaxel chemotherapy from May 2012 to March 2014 at Seoul National University Bundang Hospital. Clinical factors including prostate-specific antigen (PSA) nadir level, time to PSA nadir, PSA doubling time, PSA response, and modes of progression (PSA, radiologic, clinical) were analyzed. Disease progression was classified according to the Prostate Cancer Working Group 2 criteria.

The mean age and PSA value of the entire cohort were 76. 0±7. 2 years and 158. 8±237. 9 ng/mL, respectively. The median follow-up duration was 13. 4±6. 7 months. There were no statistically significant differences in clinical characteristics between patients who received abiraterone acetate with ADT duration

Although this was a retrospective study with a small sample size, we did not observe any statistically significant differences in the clinical response to abiraterone acetate between mCRPC patients with long ADT duration and those with short ADT duration in terms of disease progression-free survival.

Korean journal of urology. 2015 Aug 06 [Epub]

Ki Bom Kim, Jung Ki Jo, Soyeon Ahn, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee

Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Medical Research Collaborating Centre, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. , Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.

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