Differences in the aggressiveness of prostate cancer among Korean, Caucasian, and African American men: A retrospective cohort study of radical prostatectomy

We aimed to compare the pathologic aggressiveness of clinically localized prostate cancer (PCa) treated by radical prostatectomy in Korean and Western (Caucasian and African American [AA]) men by analyzing data from representative hospitals in the capitals of Korea (Seoul) and the United States (Washington, DC).

We performed a retrospective cohort study of 1,939 patients who underwent radical prostatectomy for clinically localized PCa in the Asan Medical Center and Washington Hospital Center. After adjusting for confounding clinical variables, we used multivariate logistic regression analysis to assess differences in the aggressiveness of PCa.

We analyzed 1,152 Korean, 473 Caucasian, and 314 AA patients. There were significant differences between Korean and Western patients in terms of age at surgery, preoperative levels of prostate-specific antigen, and clinical stage (P

There are differences in PCa aggressiveness between Korean and Western men. The incidence of high-grade or advanced-stage PCa is higher in Korean men.

Urologic oncology. 2015 Sep 04 [Epub ahead of print]

In Gab Jeong, Daoud Dajani, Mohan Verghese, Jonathan Hwang, Yong Mee Cho, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, Jae Y Ro

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , Department of Urology, Georgetown University School of Medicine, Washington, DC. , Department of Urology, Georgetown University School of Medicine, Washington, DC. , Department of Urology, Georgetown University School of Medicine, Washington, DC. , Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: cskim@amc. seoul. kr. , Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Pathology and Genomic Medicine, The Methodist Hospital and Weil Medical College of Cornell University, Houston, TX.

:PubMed

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