Leuprorelin is indicated for the palliative treatment of advanced prostate cancer (APC) and is available as 1, 3, 4 and 6-monthly injections. There are advantages of longer leuprorelin injection intervals in the treatment of APC.
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Across all injection intervals, efficacy is similar and the majority of patients achieve testosterone suppression and normalisation of prostate-specific antigent. Treatment is well tolerated. Six-monthly leuprorelin injections are less costly to the healthcare system than the shorter interval injections.
Australian family physician. 2015 [Epub]
BPharm PhD, Zitro Consulting Services, Artarmon, NSW; and Conjoint Associate Professor, St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW.