Leuprorelin is indicated for the palliative treatment of advanced prostate cancer (APC) and is available as 1, 3, 4 and 6-monthly injections. There are advantages of longer leuprorelin injection intervals in the treatment of APC.
Across all injection intervals, efficacy is similar and the majority of patients achieve testosterone suppression and normalisation of prostate-specific antigent. Treatment is well tolerated. Six-monthly leuprorelin injections are less costly to the healthcare system than the shorter interval injections.
Australian family physician. 2015 [Epub]
Michael Ortiz
BPharm PhD, Zitro Consulting Services, Artarmon, NSW; and Conjoint Associate Professor, St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW.