Genome-wide association study of prostate cancer-specific survival.

Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia Top findings were assessed for replication in a Norwegian cohort (CONOR).

We observed no significant association between genetic variants and prostate cancer survival.

Common genetic variants with large impact on prostate cancer survival were not observed in this study.

Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Aug 25 [Epub ahead of print]

Robert Szulkin, Robert Karlsson, Thomas Whitington, Markus Aly, Henrik Gronberg, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Melissa C Southey, Liesel FitzGerald, Brian E Henderson, Fredrick R Schumacher, Christopher A Haiman, Csilla Sipeky, Teuvo L J Tammela, Borge G Nordestgaard, Timothy J Key, Ruth C Travis, David Neal, Jenny L Donovan, Freddie C Hamdy, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Jan Lubinski, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Volker Herrmann, Bernd Holleczek, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Chavdar Slavov, Radka P Kaneva, Vanio I Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev S Pandha, Agnieszka Michael, Andrzej Kierzek, Demetrius Albanes, Gerald L Andriole, Sonja I Berndt, Stephen J Chanock, Susan M Gapstur, Edward L Giovannucci, David J Hunter, Peter Kraft, Loic Le Marchand, Jing Ma, Alison M Mondul, Kathryn L Penney, Meir Stampfer, Victoria L Stevens, Stephanie J Weinstein, Antonia Trichopoulou, H Bas Bueno-de-Mesquita, Anne Tjonneland, David G Cox, Lovise Maehle, Johanna Schleutker, Sara Lindstrom, Fredrik Wiklund

Medical epidemiology and biostatistics, Karolinska Institute robert szulkin@ki se , Karolinska Institute , Dept Biosciences and Nutrition, Karolinska Institute , Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Department of Medical Epidemiology and Biostatistics, Karolinska Institute , Oncogenetics Team, The Institute of Cancer Research, The Royal Marsden NHS National Trust , Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge , The Institute of Cancer Research , Public Health and Primary Care, University of Cambridge , University of Cambridge , The University of Manchester , Cancer Epidemiology Centre, Cancer Council Victoria , Genetic Epidemiology Laboratory, The University of Melbourne , Cancer Epidemiology Centre, Cancer Council Victoria , Preventive Medicine, Keck School of Medicine, University of Southern California , University of Southern California , University of Southern California/Norris Comprehensive Cancer Center , Department of Medical Biochemistry and Genetics, University of Turku , University of Tampere, University of Tampere , Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital , Cancer Epidemiology Unit Nuffield Department of Clinical Medicine, University of Oxford , Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford , Surgical Oncology (Uro-Oncology: S4), Addenbrooke's Hospital, University of Cambridge , School of Social and Community Medicine, University of Bristol , Nuffield Department of Surgical Sciences, University of Oxford , Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge , Department of Applied Health Research, University College London , Cambridge Institute of Public Health, University of Cambridge , Division of Public Health Sciences, Fred Hutchinson Cancer Research Center , Department of Laboratory Medicine and Pathology, Mayo Clinic , Health Science Research, Mayo Clinic , Health Science Research, Mayo Clinic , Department of Urology, University Hospital Ulm , Universität Ulm, Institut für Humangenetik , Institute for Human Genetics, University of Ulm , Department of Urology, Technical University Munich , Brigham and Women's Hospital/Dana-Farber Cancer Institute , International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University , Genetics and Pathology, Pomeranian Medical University , Genetics and Pathology, Pomeranian Medical University , Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine , Division of Clinical Epidemiology and Aging Research, German Cancer Research Center , German Cancer Research Center (DKFZ) , Saarland Cancer Registry , Cancer Epidemiology, Moffitt Cancer Center , Department of Cancer Epidemiology, Moffitt Cancer Center , Biostatistics Program, Moffitt Cancer Center , Department of Urology, Medical University-Sofia , Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University - Sofia , Department of Chemistry and Biochemistry, Molecular Medicine Center, Medical University - Sofia , Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Translational Research Institute, Queensland University of Technology , Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Translational Research Institute, Queensland University of Technology , Molecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute , Department of Genetics, Portuguese Oncology Institute, Porto, Portugal and Biomedical Sciences Institute (ICBAS) , Department of Genetics, Portuguese Oncology Institute-Porto , Department of Genetics, Portuguese Oncology Institute-Porto , Oncology, Leggett Building, University of Surrey , Oncology, University of Surrey , Department of Urology, The University of Surrey, Faculty of Health & Medical Sciences , Division of Cancer Epidemiology and Genetics, National Institiute of Health , Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine , Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health , Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Epidemiology Research Program, American Cancer Society , Department of Nutrition & Epidemiology, Harvard School of Public Health , Program in Molecular and Genetic Epidemiology, Harvard School of Public Health , Department of Epidemiology, Harvard School of Public Health , Epidemiology Program, University of Hawaii Cancer Center , Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Department of Epidemiology, University of Michigan School of Public health , Department of Epidemiology, Harvard T H Chan School of Public Health , Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School , Epidemiology Research, American Cancer Society , Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bureau of Epidemiologic Research, Academy of Athens , National Institute for Public Health and the Environment (RIVM) , Danish Cancer Society Research Center , Centre Léon Bérard, INSERM U1052, Cancer Research Center of Lyon , Oslo University Hospital , Department of Medical Biochemistry and Genetics, University of Turku , Department of Epidemiology, Harvard School of Public Health , Department of Medical Epidemiology and Biostatistics, Karolinska Institute

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