Diclofenac suppository as a preemptive analgesia in ultrasound guided biopsy of prostate: Randomized controlled trial

To compare pre-procedure Diclofenac suppository and Xylocaine gel with Xylocaine gel only in patients undergoing trans rectal ultrasound (TRUS) guided biopsy of prostate for pain.

It is a randomized controlled trial conducted on patients undergoing TRUS guided biopsy for clinical or biochemical suspicion of prostate cancer following a written informed consent and ERC approval.

Patients were randomized in two groups Group A included those patients who received Diclofenac suppository 2 hours before in combination with 10 ml of 2% Xylocaine gel 5 minutes before biopsy Group B received Xylocaine gel only A visual analog scale was used to measure the pain scores at the time of TRUS probe insertion, just after taking biopsy cores and 2 hours after biopsy

A total of 100 patients were recruited in the study with 50 patients each in Group A and B Mean age of Group A was 69 1±10 years and 67 3±8 1 years for Group B The mean pain score for group A and B at the time of probe insertion was 0 08+0 27 and 0 34+0 63 (p= 0 032), immediately after taking biopsy cores was 1 46+1 15 and 4 68+0 77 (p 0 000) and 2 hours after biopsy was 0 14+0 45 versus 2 40+0 81(p 0 000) respectively

The mean pain score at the time of TRUS probe insertion, immediately after taking biopsy cores and 2 hours after biopsy is statistically significantly higher in-group B

Urology 2015 Jul 29 [Epub ahead of print]

Naveed Haroon, M Hammad Ather, Salma Khan, Pirkash Kumar, Basit Salam



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