High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.

Hook microtubule-tethering protein 3 (HOOK3) is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking. In order to assess the role of HOOK3 in prostate cancer we analyzed HOOK3 expression by immunohistochemistry on a TMA containing more than 12,400 prostate cancers.

Results were compared to tumor phenotype and PSA recurrence as well as aberrations possibly defining relevant molecular subtypes such as ERG status and deletions of 3p13, 5q21, 6q15 and PTEN HOOK3 immunostaining was negative in normal luminal cells of prostate epithelium, whereas 53 3% of 10,572 interpretable cancers showed HOOK3 expression, which was considered low in 36 4% and high in 16 9% of cases High-level HOOK3 expression was linked to advanced tumor stage, high Gleason score, high proliferation index, positive lymph node stage, and PSA recurrence (p

PloS one 2015 Jul 31*** epublish ***

Nathaniel Melling, Levon Harutyunyan, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Patrick Lebok, Sarah Minner, Maria Christina Tsourlakis, Christina Koop, Markus Graefen, Meike Adam, Alexander Haese, Corinna Wittmer, Stefan Steurer, Jakob Izbicki, Guido Sauter, Waldemar Wilczak, Thorsten Schlomm, Till Krech

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany , Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany , Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany , Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany; Department of Urology, Section for translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Germany , Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany

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