Androgen deprivation therapy (ADT) has been the mainstay of treatment for advanced prostate cancer for decades, and has been shown to control disease and improve symptoms. In addition, for men with high-risk localized or locally advanced prostate cancer, short-course ADT in combination with radiotherapy improves survival.
There is evidence that ADT increases cardiovascular risk, particularly in men with preexisting cardiovascular disease This increased risk may apply even with short-course ADT In an individual patient, the benefits of ADT should be balanced against the risk, and patients who require ADT should have risk factors for cardiovascular disease optimized There is some evidence to suggest that more contemporary methods of delivering ADT may reduce cardiovascular risk
Drug, healthcare and patient safety 2015 Jul 23*** epublish ***
Jason F Lester, Malcolm D Mason
Velindre Hospital, Whitchurch, Cardiff University, Heath Park, Cardiff, UK , Velindre Hospital, Whitchurch, Cardiff University, Heath Park, Cardiff, UK ; School of Medicine, Cardiff University, Heath Park, Cardiff, UK