DWI-associated entire-tumor histogram analysis for the differentiation of low-grade prostate cancer from intermediate-high-grade prostate cancer.

To investigate diagnostic efficiency of DWI using entire-tumor histogram analysis in differentiating the low-grade (LG) prostate cancer (PCa) from intermediate-high-grade (HG) PCa in comparison with conventional ROI-based measurement.

DW images (b of 0-1400 s/mm(2)) from 126 pathology-confirmed PCa (diameter >0 5 cm) in 110 patients were retrospectively collected and processed by mono-exponential model The measurement of tumor apparent diffusion coefficients (ADCs) was performed with using histogram-based and ROI-based approach, respectively The diagnostic ability of ADCs from two methods for differentiating LG-PCa (Gleason score, GS ≤6) from HG-PCa (GS > 6) was determined by ROC regression, and compared by McNemar's test

There were 49 LG-tumor and 77 HG-tumor at pathologic findings Histogram-based ADCs (mean, median, 10th and 90th) and ROI-based ADCs (mean) showed dominant relationships with ordinal GS of Pca (ρ = -0 225 to -0 406, p < 0 05) All above imaging indices reflected significant difference between LG-PCa and HG-PCa (all p values

DWI-associated histogram analysis had higher specificity, Az, Youden index, and LR+ for differentiation of PCa Gleason grade than ROI-based approach

Abdominal imaging 2015 Jul 09 [Epub ahead of print]

Chen-Jiang Wu, Qing Wang, Hai Li, Xiao-Ning Wang, Xi-Sheng Liu, Hai-Bin Shi, Yu-Dong Zhang

Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No 300, Guangzhou Road, Nanjing, 210000, China