Are biomarkers evaluated in biopsy specimens predictive of prostate cancer aggressiveness?

To evaluate biomarkers involved in biological pathways for prostate cancer (PCa) progression, measured in biopsy specimens, in order to distinguish patients at higher risk for fatal PCa and thus improve the initial management of disease.

Retrospective case-control study In 129 PCa patients who underwent ultrasound-guided needle prostate biopsy and subsequent radical prostatectomy from 1987 to 1999 at the University Hospital of Careggi, we evaluated: (1) mRNA expression of the serine 2 (TMPRSS2): erythroblastosis virus E26 oncogene homolog (ERG); (2) expression of matrix metalloproteinases (MMP)-2 and 9 (epithelial and stromal); (3) expression of androgen receptor; (4) expression of prognostic marker Ki67 (MIB1); (5) presence and typing of human papilloma virus; (6) DNA methylation of CpG islands of several genes involved in PCa progression

The cohort consists of 38 cases (patients with PCa and died of PCa within 10 years from diagnosis) and 91 controls (patients with PCa but alive 10 years after diagnosis) Gleason bioptic score, epithelial MMP expression and SERPINB5 methylation correlated with statistically significant increase in death risk OR Compared with patients with high level of MMP, patients with low level of MMP had OR for specific death 4 78 times higher (p = 0 0066) After adjustment for age and Gleason score, none of the investigated biomarkers showed increased OR for PCa death

Our preliminary results suggest that evaluation, in prostate biopsy specimens, of a panel of biomarkers known to be involved in PCa progression is poorly indicative of tumor outcome

Journal of cancer research and clinical oncology 2015 Jul 26 [Epub ahead of print]

Francesca Carozzi, Lara Tamburrino, Simonetta Bisanzi, Sara Marchiani, Milena Paglierani, Simonetta Di Lollo, Emanuele Crocetti, Carlotta Buzzoni, Elena Burroni, Luana Greco, Elisabetta Baldi, Cristina Sani

Laboratory Cancer Prevention, Cancer Prevention and Research Institute (ISPO), Via Cosimo il Vecchio 2, 50139, Florence, Italy



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