Contemporary Population-Based Comparison of Localized Ductal Adenocarcinoma and High-Risk Acinar Adenocarcinoma of the Prostate

To compare pathologic characteristics, treatment patterns and survival in patients with ductal adenocarcinoma (DC) compared to those with acinar adenocarcinoma (AC).

Using the National Cancer Database (NCDB), we identified patients diagnosed with clinically localized (cN0, cM0) pure DC (n=1,328) and AC (n=751,635) between 1998 and 2011.

High-risk AC was defined as Gleason 8-10 Demographic, treatment, pathological and survival characteristics of patients were compared

Compared to patients with Gleason 8-10 AC, those with DC presented with lower mean PSA (10 3 vs 16 2 ng/mL, p

In this large contemporary population-based series, patients with ductal adenocarcinoma of the prostate presented with lower PSA, had more favorable pathologic features, and similar overall survival compared to men with Gleason 8-10 AC

Urology 2015 Jul 18 [Epub ahead of print]

Vignesh T Packiam, Sanjay G Patel, Joseph J Pariser, Kyle A Richards, Adam B Weiner, Gladell P Paner, David J VanderWeele, Gregory P Zagaja, Scott E Eggener

Section of Urology, University of Chicago, Chicago, IL Electronic address: vignesh packiam@uchospitals edu , Section of Urology, University of Chicago, Chicago, IL , Section of Urology, University of Chicago, Chicago, IL , Department of Urology, University of Wisconsin-Madison, Madison, WI , Pritzker School of Medicine, The University of Chicago Medical Center, Chicago, IL , Department of Pathology, University of Chicago, Chicago, IL , Institute for Genomics and Systems Biology, Department of Medicine, University of Chicago, Chicago, IL , Section of Urology, University of Chicago, Chicago, IL , Section of Urology, University of Chicago, Chicago, IL

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