Tumor diameter is a reliable parameter to estimate tumor volume in solid organ cancers; its use in prostate cancer is controversial since it exhibits a more irregular pattern of growth. This study aimed to examine the association between the tumor volume estimations based on transrectal ultrasound (TRUS) guided biopsy results and the tumor volume measured on the pathological specimen.
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A total of 237 patients who underwent radical retropubic prostatectomy (RRP) were included in this retrospective study The differences and correlations between cancer volume estimations based on TRUS guided biopsy findings and cancer volume estimations based on post-prostatectomy pathology specimens were examined In addition, diagnostic value of TRUS guided biopsy-based volume estimations in order to predict clinically significant cancer (>0 5 cc) were calculated
The mean cancer volume estimated using TRUS biopsy results was lower (5 5±6 5 cc) than the mean cancer volume calculated using prostatectomy specimens (6 4±7 6 cc) (p
TRUS guided biopsy-derived estimations seem to have a limited value to predict pathologically established tumor volume Further studies are warranted to identify additional methods that may more accurately predict actual pathological characteristics and prognosis of prostate cancer
International braz j urol : official journal of the Brazilian Society of Urology 0000 [Epub]
Ersin Konyalioglu, Huseyin Tarhan, Ozgur Cakmak, Emel Ebru Pala, Ferruh Zorlu
Department of Urology, Milas 75 Yil State Hospital, Mugla, Turkey , Department of Urology, Tepecik Research and Training Hospital, Izmir, Turkey , Department of Urology, Tepecik Research and Training Hospital, Izmir, Turkey , Department of Pathology, Tepecik Research and Training Hospital, Izmir, Turkey , Department of Urology, Tepecik Research and Training Hospital, Izmir, Turkey