Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures

Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells.

The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture.

Adv Healthc Mater. 2015 Aug;4(11):1664-74. doi: 10.1002/adhm.201500258. Epub 2015 Jun 9.

Engel BJ1, Constantinou PE1, Sablatura LK1, Doty NJ2, Carson DD1, Farach-Carson MC1, Harrington DA1, Zarembinski TI2.

1 Department of BioSciences, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
2 BioTime, Incorporated, 1301 Harbor Bay Parkway, Alameda, CA, 94502, USA.