PURPOSE/OBJECTIVES - To determine whether exercise could reduce biomarkers of cancer progression in prostate cancer survivors (PCSs) on androgen-deprivation therapy (ADT). .
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
DESIGN - Randomized, controlled trial. .
SETTING - Oregon Health and Science University School of Nursing. .
SAMPLE - 51 PCSs randomized to one year of resistance and impact training or a stretching control group. .
METHODS - The authors investigated changes in body composition and cancer-related biomarkers, and the influence of age and fat loss on changes in biomarkers. .
MAIN RESEARCH VARIABLES - Body composition (total fat, trunk fat, and lean mass), insulin, insulin-like growth factor-1, and sex hormone-binding globulin. .
FINDINGS - In the 36 PCSs with baseline and 12-month data, total fat (p = 0.02) and trunk fat (p = 0.06) mass decreased in the training group compared to gains in controls. Loss of total and trunk fat each mediated the relationship between groups and one-year change in insulin (p < 0.05). Age moderated the insulin response to exercise where insulin reductions were smaller with increasing age (p = 0.03). .
CONCLUSIONS - Resistance and impact exercise may reduce body fat among PCSs undergoing ADT, in turn exerting an insulin-lowering effect. .
IMPLICATIONS FOR NURSING - Nurses should counsel PCSs to exercise to reduce the risk of obesity and associated conditions, including cancer progression. .
Oncol Nurs Forum. 2015 Jul 1;42(4):348-56. doi: 10.1188/15.ONF.348-356.
Winters-Stone KM1, Dieckmann N2, Maddalozzo GF3, Bennett JA4, Ryan CW4, Beer TM4.
1 School of Nursing, Oregon Health and Science University, Portland.
2 Oregon Health and Science University in Portland.
3 Oregon State University in Corvallis.
4 Knight Cancer Institute at Oregon Health and Science University.