Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score - Abstract

To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS >7) from low-grade GS (GS≤ 7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included.

Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were Ktrans=0.184min-1, Kep=0.695min-1, iAUC=4.219mmol/l/min, and ADC=1340.5mm2/s. A significant difference in mean values of Ktrans and Kep between cancer with high-grade GS and low-grade GS was also observed. Ktrans and Kep showed a significant correlation with GS.

Written by:
Cho E, Chung DJ, Yeo DM, Sohn D, Son Y, Kim T, Hahn ST.   Are you the author?
Department of Radiology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713; Department of Urology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713; Imaging and Therapy Systems Division, SIEMENS Healthcare Korea, Poongsan Building 6th Floor, 23, Chungjeong-ro, Seodaemun-gu, Seoul, Korea, 120-714; Department of Pathology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713.  ; ; ; ; ; ;

Reference: Clin Imaging. 2015 May 7. pii: S0899-7071(15)00112-6.
doi: 10.1016/j.clinimag.2015.04.020


PubMed Abstract
PMID: 26001659

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