BACKGROUND AND PURPOSE: The aim of this study was to evaluate chronologic changes in lower urinary tract symptoms (LUTS), health-related (HR) quality of life (QOL), and disease-specific QOL during the first 12months after salvage radiotherapy (SRT) for biochemical recurrence of prostate cancer in patients who underwent radical prostatectomy.
MATERIALS AND METHODS: In 81 patients who received SRT (70Gy/35fr/7weeks), International Prostate Symptom Score (IPSS), 36-Item Short Form scores, and UCLA-Prostate Cancer Index (UCLA-PCI) were recorded before, during, and immediately after SRT, and 1-12months after the completion of SRT.
RESULTS: The total IPSS and storage symptom-related sum were significantly increased following initiation of SRT, and returned to the baseline 6months after SRT. For three of eight domains of HRQOL, and the physical component summary score showed transient deterioration in the period between completion of SRT and 1month following SRT. The UCLA-PCI for urinary function/bother and bowel function/bother was affected until 1-6months after SRT.
CONCLUSIONS: This is the first report to concurrently evaluate detailed chronologic changes in LUTS and QOL in patients who received SRT. Knowledge of changes in LUTS and QOL outcomes associated with SRT may influence treatment recommendations and enable patients to make better-informed decisions.
Miyake M, Tanaka N, Asakawa I, Tatsumi Y, Nakai Y, Anai S, Torimoto K, Aoki K, Yoneda T, Hasegawa M, Konishi N, Fujimoto K. Are you the author?
Department of Urology, Nara Medical University, Japan; Department of Radiation Oncology, Nara Medical University, Japan; Department of Pathology, Nara Medical University, Japan.
Reference: Radiother Oncol. 2015 May 16. pii: S0167-8140(15)00235-2.