Histological outcomes after focal high-intensity focused ultrasound and cryotherapy - Abstract

INTRODUCTION: Focal therapy has increasingly become an accepted treatment option for patients with localised prostate cancer.

Most follow-up protocols use a mixture of protocol biopsies or "for cause" biopsies triggered by a rising PSA. In this paper, we discuss the histological outcomes from these biopsies and their use in guiding subsequent management and trial development.

METHODS: We conducted a literature search and reviewed the post-treatment biopsy results from studies on focal HIFU and focal cryotherapy. We subsequently reviewed the results of three recently published consensus statements released discussing many of the issues concerning focal therapy.

RESULTS: Research suggests that 1 in 5 of all post-treatment biopsies after focal therapy are positive. However, the majority of these seemed to be from the untreated portion of the gland or met criteria for clinically insignificant disease. The histological outcomes from focal therapy are promising and confirm its effectiveness in the short to medium term. Furthermore re-treatment is possible whilst maintaining a low-side-effect profile.

CONCLUSION: Debate is ongoing about the clinical significance of various levels of residual disease after focal therapy and the exact threshold at which to call failure within a patient who has had focal therapy.

Written by:
Shah TT, Kasivisvanathan V, Jameson C, Freeman A, Emberton M, Ahmed HU.   Are you the author?
Division of Surgery and Interventional Science, Urology Research Group, UCL, Room 4.23, 4th Floor, 132 Hampstead Road, London, NW1 2PS, UK.  

Reference: World J Urol. 2015 May 6. Epub ahead of print.
doi: 10.1007/s00345-015-1561-0

PubMed Abstract
PMID: 25944676

UroToday.com Prostate Cancer Section


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.