Multiparametric prostate magnetic resonance imaging at 3 T: Failure of magnetic resonance spectroscopy to provide added value - Abstract

PURPOSE: To assess the effect of proton magnetic resonance spectroscopy imaging (MRSI) on the accuracy of multiparametric magnetic resonance imaging (mpMRI) at 3 T for prostate cancer detection.

MATERIALS AND METHODS: Thirty-four patients with prostate cancer were included in this retrospective study. All patients underwent preoperative mpMRI on a 3-T scanner before radical prostatectomy. Magnetic resonance imaging evaluation was based on the prostate imaging-reporting and data system classification system. The accuracy of mpMRI with and without MRSI was determined using receiver operating characteristic analysis, with histology as the reference standard.

RESULTS: Multiparametric MRI including MRSI had a sensitivity of 57.0% and a specificity of 89.2% for sextant-based cancer detection. Multiparametric MRI without MRSI had a sensitivity of 58.1% and a specificity of 87.4%. There was no significant difference regarding the accuracy of mpMRI with and without MRSI (P = 0.48).

CONCLUSION: The addition of MRSI does not improve the accuracy of 3 T mpMRI for sextant localization of prostate cancer.

Written by:
Platzek I, Borkowetz A, Toma M, Brauer T, Meissner C, Dietel K, Wirth M, Laniado M.   Are you the author?
Departments of Radiology, Urology, and Pathology, Dresden University Hospital, Dresden, Germany.

Reference: J Comput Assist Tomogr. 2015 May 1. Epub ahead of print.
doi: 10.1097/RCT.0000000000000261

PubMed Abstract
PMID: 25938212 Prostate Cancer Section