Cardiometabolic and skeletal risk factors in black men with prostate cancer starting androgen deprivation therapy - Abstract

BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with multiple metabolic complications, previously predominantly evaluated in the white population.

METHODS: A chart-based retrospective review was conducted on black patients with PCa, considered for ADT, from September 2007 to July 2010. Baseline data were collected on body mass index (BMI), vitamin-D status, bone mineral density (BMD), dyslipidemia and diabetes. Overweight and obesity were classified as BMI ≥ 25 and BMI ≥ 30, respectively. Vitamin-D sufficiency was defined as levels ≥30 ng/mL, insufficiency as < 30 ng/mL and deficiency as ≤ 20 ng/mL. Osteopenia was defined as T scores between -1 to -2.5 and osteoporosis when T scores ≤ -2.5.

RESULTS: Of the initial cohort of 130 black men, 111 (85.4%) patients underwent ADT. At baseline, average BMI was 28.1 ± 5.9 with 43.3% of men being overweight and 30.8% obese. More than one-third of the patients had pre-existing dyslipidemia while 28.8% were diabetics. 50% were vitamin-D deficient while 41% had low bone mass.

CONCLUSIONS: Black men with PCa presenting for consideration of ADT have a high prevalence of existing metabolic risk factors. Close monitoring of this patient population is needed during ADT to prevent and treat metabolic complications.

Written by:
Gunnarsson O, Basaria S, Gignac GA.   Are you the author?
Department of Medicine, Division of Hematology and Oncology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 16 Penn Tower, Philadelphia, PA 19104, USA; Department of Medicine, Section of Men's Health, Aging and Metabolism, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Section of Hematology and Oncology, Boston University School of Medicine, Boston, MA 02118, USA. ; ; ;

Reference: Cancers (Basel). 2015 Apr 22;7(2):679-87.
doi: 10.3390/cancers7020679

PubMed Abstract
PMID: 25913100 Prostate Cancer Section