PURPOSE: Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics.
METHODS: Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) were prospectively examined in men diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-up Study (n = 1917) using generalized linear models.
RESULTS: After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, < 0.0001). Effects were small (d = 0.16-0.20) but approached clinical significance for men in the highest vs. lowest activity categories. Survivors who walked ≥90 min/week at a normal pace, or faster, reported higher hormone/vitality scores (p = 0.001) than men walking < 90 min at an easy pace. Weightlifting was associated with increased urinary incontinence (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in men who were ≥5 years post-treatment, had more advanced disease (Gleason score ≥7), and had ≥1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL.
CONCLUSIONS: Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in ≥5 h of non-vigorous activity or ≥3 h of walking per week may be beneficial.
IMPLICATIONS FOR CANCER SURVIVORS: Encouraging men to engage in non-vigorous activity and walking may be helpful for managing prostate cancer-related HRQOL.
Phillips SM, Stampfer MJ, Chan JM, Giovannucci EL, Kenfield SA. Are you the author?
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
Reference: J Cancer Surviv. 2015 Apr 16. Epub ahead of print.