Cognitive function in Chinese prostate cancer patients on androgen-deprivation therapy: A cross-sectional study - Abstract

AIMS: Androgen-deprivation therapy (ADT) is a main treatment option for patients with prostate cancer (PCa), but its effect on cognition remains unclear.

The primary purpose of this cross-sectional case-control study was to evaluate the effects of ADT on cognition in Chinese PCa patients.

METHODS: Participants included PCa patients who had undergone ADT (ADT group, n = 33) and patients who did not undergo ADT (non-ADT group, n = 32), as well as age- and education-matched healthy controls (HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance.

RESULTS: The ADT group obtained significantly worse scores than the non-ADT and HC groups in the following neuropsychological tests: Recognition (P < 0.01), WAIS Digit Span forward (P < 0.05), Trailmaking B (P < 0.01) and Stroop Interference test (P < 0.01). No significant difference was found between the non-ADT and HC groups (P > 0.05).

CONCLUSIONS: Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.

Written by:
Yang J, Zhong F, Qiu J, Wang K.   Are you the author?
Department of Neurology, The Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.

Reference: Asia Pac J Clin Oncol. 2015 Apr 9. Epub ahead of print.
doi: 10.1111/ajco.12347

PubMed Abstract
PMID: 25856786 Prostate Cancer Section